Nis thyroid
WebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide … WebOct 31, 2012 · NIS-mediated iodide uptake also forms the basis for the diagnostic nuclear imaging and radioiodine therapy for thyroid diseases. Radioiodine therapy following NIS gene transfer was shown to be efficient in nonthyroid, especially, liver cancer models. NIS is expressed in many cancers, among them cancer of the thyroid, breast, and liver .
Nis thyroid
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The lack of iodide transport inside follicular cells tends to cause goitres. There are some mutations in the NIS DNA that cause hypothyroidism and thyroid dyshormonogenesis. Moreover, antibodies anti-NIS have been found in thyroid autoimmune diseases. Using RT-PCR tests, it has been proved that there is no expression of NIS in cancer cells (which forms a thyroid carcinoma). Nevertheless, thanks to immunohistochemical techniques it is known that NIS is no… WebMay 30, 2024 · thyroid cancer; radioiodine therapy; NIS; reactive oxygen species 1. Introduction The unique ability of the thyroid gland to accumulate iodide (I −) is the basis of radioiodine (RAI) therapy, which has been used for decades as an effective therapy for differentiated thyroid cancer (DTC) treatment [ 1, 2 ].
WebMay 10, 2024 · The pathway controls the expression of NIS, Tg, TPO and TSHR, through thyroid-specific transcription factors , and regulates Tg macrocytosis and … WebSep 25, 2024 · Objectives: To examine the prevalence of genetic alterations of thyroid-stimulating hormone receptor ( TSHR) gene and sodium-iodine symporter ( NIS) in a series of thyroid fine needle biopsy (FNB) specimens with indeterminate cytology, and to assess the correlation of the type of genetic changes with clinical features and follow-up results …
WebSep 25, 2024 · Objectives: To examine the prevalence of genetic alterations of thyroid-stimulating hormone receptor (TSHR) gene and sodium-iodine symporter (NIS) in a series … WebJul 15, 2024 · Iodide is a fundamental component of thyroid hormone and is actively imported into thyroid follicular cells by a basilar membrane-bound protein, the sodium-iodide symporter (NIS) . A functional NIS is required for the active concentration of radioactive iodine within the thyroid gland where it is incorporated into colloid and degrades into beta ...
WebMay 27, 1997 · The cDNA encoding NIS was recently cloned by functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5 cells) in Xenopus laevis oocytes ().The proposed secondary structure model suggests that NIS is an intrinsic membrane protein (≈65.2 kDa predicted molecular weight) with 12 putative transmembrane domains …
WebSodium Iodide Symporter, Sodium iodide symporter gene, thyroid . INTRODUCTION. Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the … east coast beaches in north carolinaWebFeb 1, 2014 · The Na + /I − symporter (NIS) is the plasma membrane glycoprotein that mediates active I − transport in the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. cube meat dicing machineWebApr 1, 2024 · This talk will provide an overview of the screening of ToxCast chemicals for sodium-iodide symporter (NIS) inhibition, the first step in the biosynthesis of thyroid … east coast beach vacations rentalsWebJul 15, 2024 · Most thyroid imaging techniques capitalize on some phase of hormone synthesis within the thyroid gland. Iodides or iodide analogs are actively transported by the glycoprotein sodium iodide symporter (NIS) … cube menswear liverpoolWebSep 3, 2024 · The sodium/iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal … east coast bedding down pillow reviewWebOct 12, 2024 · The NIS is a membrane glycoprotein that transports two sodium ions and one iodide ion into the cytosol of benign and tumorous thyroid cells from extracellular fluid (1–3). Since radioiodine also can be taken up by the NIS, radioiodine can be used to visualize or selectively kill DTC cells. east coast beauty supply sewell njWebThyroid scan: In this test, 2 mili Curie of 99m TC is injected intravenously to the patient and scan is done after 20 minutes to see functional status , the size and shape of thyroid … east coast bearings